Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 7/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | DRD3 | P35462 | 2/20 | 0.71 |
| ▸ | CNR1 | P21554 | 1/20 | 0.71 |
| ▸ | APEX1 | P27695 | 1/20 | 0.71 |
| ▸ | PDE4A | P27815 | 1/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.71 |
| ▸ | HTR2B | P41595 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.71 |
| ▸ | DRD2 | P14416 | 1/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | CYP2J2 | P51589 | 6/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11977258 | 0.92 | HRH1 (0.72) | HRH1KCNH2LMNADRD3CNR1 | |
| SCHEMBL18609220 | 0.90 | HRH1 (0.75) | HRH1KCNH2LMNADRD3CNR1 | |
| SCHEMBL17023752 | 0.89 | HRH1 (0.80) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL18609381 | 0.88 | HRH1 (0.79) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL18609237 | 0.85 | HRH1 (1.00) | HRH1KCNH2CYP2J2CYP3A4CYP2C9 | |
| SCHEMBL17023779 | 0.85 | HRH1 (0.80) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL20306199 | 0.85 | HRH1 (1.00) | HRH1KCNH2CYP2J2CYP3A4CYP2C9 | |
| SCHEMBL18609138 | 0.84 | HRH1 (0.80) | HRH1KCNH2CYP2J2 | |
| SCHEMBL18609403 | 0.84 | HRH1 (0.80) | HRH1KCNH2CYP2J2 | |
| SCHEMBL1395734 | 0.84 | CYP2J2 (0.84) | HRH1KCNH2LMNADRD3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10004701-B2 | Methods and compositions for treating infection | UNIVERSITY OF ROCHESTER (US) | 2018-06-26 | — | — | US | disclosed |
| US-20170065540-A1 | METHODS AND COMPOSITIONS FOR TREATING INFECTION | UNIVERSITY OF ROCHESTER (US) | 2017-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170065540-A1 | METHODS AND COMPOSITIONS FOR TREATING INFECTION | MMP8, IFNG, MPO | HRH1 1562/4885KCNH2 1413/4885LMNA 1841/4885 |
| US-10004701-B2 | Methods and compositions for treating infection | MMP8, IFNG, MPO | HRH1 1562/4885KCNH2 1413/4885LMNA 1841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.