Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 7/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 9/20 | 0.33 |
| ▸ | CTSS | P25774 | 8/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 4/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18616018 | 0.94 | LMNA (0.37) | LMNAGAAALDH1A1CTSLCYP2D6 | |
| SCHEMBL18615975 | 0.92 | CTSL (0.35) | LMNAGAAALDH1A1CTSLCYP2D6 | |
| SCHEMBL20341794 | 0.89 | CTSL (0.34) | LMNAGAAALDH1A1CTSLCTSK | |
| SCHEMBL18616629 | 0.88 | CTSL (0.37) | CTSLCTSKCTSSCTSB | |
| SCHEMBL23810244 | 0.88 | LMNA (0.35) | LMNAGAAALDH1A1CTSLCTSK | |
| SCHEMBL20341792 | 0.87 | CTSL (0.36) | CTSLCYP2D6CTSKCTSSHPGD | |
| SCHEMBL18615942 | 0.85 | CTSK (0.41) | CTSLCTSKCTSSCTSB | |
| SCHEMBL18615946 | 0.85 | CACNA1H (0.40) | CTSLCYP2D6CTSKCTSS | |
| SCHEMBL23810230 | 0.85 | CTSL (0.34) | LMNAGAACTSLCYP2D6CTSK | |
| SCHEMBL18615974 | 0.84 | NAMPT (0.33) | CTSLCYP2D6CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342765-A1 | CATHEPSIN K INHIBITOR AND APPLICATION THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017036357-A1 | CATHEPSIN K INHIBITOR AND APPLICATION THEREOF | 广东东阳光药业有限公司 | 2017-03-09 | — | — | WO | disclosed |