Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TPO | P07202 | 1/20 | 0.32 |
| ▸ | EPX | P11678 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18617396 | 0.68 | — | — | |
| SCHEMBL19723292 | 0.67 | NPSR1 (0.37) | CYP3A4MEN1ALDH1A1CYP2C19KMT2A | |
| SCHEMBL18617434 | 0.67 | MPO (0.40) | MPOCYP3A4TPOEPX | |
| SCHEMBL22958918 | 0.64 | TDP1 (0.42) | CYP3A4MEN1ALDH1A1CYP2C19KMT2A | |
| SCHEMBL18616509 | 0.63 | MPO (0.39) | MPOCYP3A4TPOEPX | |
| SCHEMBL24044792 | 0.63 | POLB (0.38) | CYP3A4ALDH1A1CYP2C19KMT2A | |
| SCHEMBL18616672 | 0.63 | NPSR1 (0.31) | CYP3A4MEN1ALDH1A1CYP2C19KMT2A | |
| SCHEMBL22587209 | 0.62 | ALDH1A1 (0.35) | MEN1ALDH1A1KMT2A | |
| SCHEMBL18617402 | 0.62 | MPO (0.33) | MPOMEN1KMT2A | |
| SCHEMBL22110636 | 0.61 | TAS2R14 (0.46) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040449-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |