Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | WDR5 | P61964 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GNRHR | P30968 | 1/20 | 0.46 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.44 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13947456 | 0.87 | MAPT (0.54) | MAPTWDR5P2RX3P2RX2 | |
| SCHEMBL10263733 | 0.84 | WDR5 (0.48) | WDR5GNRHRP2RX3P2RX2 | |
| SCHEMBL5791965 | 0.84 | P2RX3 (0.53) | MAPTWDR5LMNAPOLBALDH1A1 | |
| SCHEMBL1568296 | 0.83 | WDR5 (0.50) | MAPTL3MBTL1WDR5LMNAALDH1A1 | |
| SCHEMBL8376682 | 0.80 | KDM4E (0.57) | MAPTL3MBTL1POLBALDH1A1CYP1A2 | |
| SCHEMBL13450235 | 0.80 | EPHX2 (0.52) | MAPTWDR5P2RX3P2RX2 | |
| SCHEMBL17888443 | 0.77 | HDAC1 (0.50) | MAPTWDR5PLK1LMNAMAPK1 | |
| SCHEMBL13947315 | 0.77 | POLB (0.56) | L3MBTL1WDR5POLBATMP2RX3 | |
| SCHEMBL8404650 | 0.76 | LMNA (0.70) | L3MBTL1LMNAPOLBALDH1A1HPGD | |
| SCHEMBL9999549 | 0.76 | P2RX3 (0.49) | MAPTWDR5P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040449-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |