Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I3 | Q14994 | 17/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14740335 | 0.91 | LMNA (0.46) | NR1I3ALDH1A1NR1I2DPP4LMNA | |
| SCHEMBL14740306 | 0.87 | NR1I3 (0.45) | NR1I3ALDH1A1DPP4LMNAHSD17B10 | |
| SCHEMBL14740449 | 0.85 | NR1I3 (0.45) | NR1I3ALDH1A1DPP4LMNAHSD17B10 | |
| SCHEMBL18622357 | 0.84 | P2RX7 (0.41) | NR1I3ALDH1A1LMNAHSD17B10CYP1A2 | |
| SCHEMBL14739184 | 0.83 | ALDH1A1 (0.50) | NR1I3ALDH1A1NR1I2DPP4LMNA | |
| SCHEMBL18622362 | 0.83 | NR1I3 (0.44) | NR1I3ALDH1A1NR1I2DPP4CYP1A2 | |
| SCHEMBL14745122 | 0.78 | KCNN4 (0.42) | NR1I3ALDH1A1NR1I2DPP4 | |
| SCHEMBL14739635 | 0.78 | L3MBTL1 (0.44) | ALDH1A1LMNAHSD17B10 | |
| SCHEMBL14740234 | 0.76 | ALDH1A1 (0.43) | NR1I3ALDH1A1LMNAHSD17B10CYP1A2 | |
| SCHEMBL14740387 | 0.75 | DPP4 (0.42) | NR1I3ALDH1A1NR1I2DPP4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9593109-B2 | Bicyclic agonists of GPR131 and uses thereof | CYMABAY THERAPEUTICS, INC. (US) | 2017-03-14 | — | — | US | disclosed |