Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.64 |
| ▸ | TERT | O14746 | 2/20 | 0.56 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | NSD2 | O96028 | 2/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9239646 | 0.93 | NQO1 (0.71) | NQO1TERTMALT1KMT2AMEN1 | |
| SCHEMBL22196771 | 0.87 | NQO1 (0.65) | NQO1TERTMALT1KMT2AMEN1 | |
| SCHEMBL22196654 | 0.87 | NQO1 (0.65) | NQO1TERTMALT1KMT2AMEN1 | |
| SCHEMBL17241822 | 0.87 | NQO1 (0.68) | NQO1TERTMALT1KMT2AMEN1 | |
| SCHEMBL17241793 | 0.86 | NQO1 (0.64) | NQO1TERTMALT1KMT2AMEN1 | |
| SCHEMBL20334354 | 0.86 | NQO1 (0.77) | NQO1TERTMALT1KMT2AMEN1 | |
| SCHEMBL9239538 | 0.85 | MALT1 (0.66) | NQO1TERTMALT1KMT2AMEN1 | |
| SCHEMBL17241777 | 0.84 | NQO1 (0.61) | NQO1TERTMALT1KMT2AMEN1 | |
| SCHEMBL17241768 | 0.84 | NQO1 (0.60) | NQO1TERTMALT1KMT2AMEN1 | |
| SCHEMBL17241769 | 0.84 | TOP2B (0.66) | NQO1TERTMALT1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9980936-B2 | BH4 antagonists and methods related thereto | EMORY UNIVERSITY (US) | 2018-05-29 | — | — | US | disclosed |
| US-20170071896-A1 | BH4 Antagonists and Methods Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-03-16 | — | — | US | disclosed |
| US-20170071896-A1 | BH4 Antagonists and Methods Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170071896-A1 | BH4 Antagonists and Methods Related Thereto | BHMT, BHMT2, SHMT2 | NQO1 17/4885TERT 2576/4885MALT1 2096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.