Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 9/20 | 0.53 |
| ▸ | PARP15 | Q460N3 | 8/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18640136 | 0.99 | PARP10 (0.54) | PARP10PARP15MAOAMAOBSGK1 | |
| SCHEMBL18639866 | 0.94 | PARP15 (0.51) | PARP10PARP15MAOAMAOBPDPK1 | |
| SCHEMBL18639956 | 0.89 | SLC6A2 (0.53) | PARP10PARP15MAOAMAOBROCK1 | |
| SCHEMBL18639981 | 0.86 | MAOA (0.50) | PARP10PARP15MAOAMAOB | |
| SCHEMBL18640011 | 0.84 | SLC6A2 (0.55) | PARP10PARP15PDPK1JAK2ROCK1 | |
| SCHEMBL18639909 | 0.84 | CHEK1 (0.44) | PARP10PARP15MAOAMAOB | |
| SCHEMBL18639974 | 0.83 | CHEK1 (0.45) | PARP10PARP15MAOAMAOB | |
| SCHEMBL18664031 | 0.83 | PRKCZ (0.53) | — | |
| SCHEMBL18639846 | 0.82 | CYP4F2 (0.41) | PARP10PARP15 | |
| SCHEMBL18639875 | 0.82 | DRD2 (0.43) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017045751-A1 | COMPOUNDS AS ASIC INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-03-23 | — | — | WO | disclosed |
| WO-2017045751-A1 | COMPOUNDS AS ASIC INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-03-23 | — | — | WO | disclosed |