Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30493712 | 1.00 | ABCG2 (0.38) | ABCG2 | |
| Hydrochloric Acid SCHEMBL7340960 | 0.98 | ABCG2 (0.37) | ABCG2 | |
| SCHEMBL3647981 | 0.85 | ABCG2 (0.34) | ABCG2 | |
| SCHEMBL3378055 | 0.73 | ABCG2 (0.37) | ABCG2 | |
| SCHEMBL8987959 | 0.68 | ABCG2 (0.33) | ABCG2 | |
| SCHEMBL1870999 | 0.67 | ABCG2 (0.38) | ABCG2 | |
| SCHEMBL4555851 | 0.62 | IDO1 (0.37) | — | |
| SCHEMBL30019213 | 0.62 | ABCG2 (0.62) | ABCG2 | |
| SCHEMBL261676 | 0.62 | ABCG2 (0.62) | ABCG2 | |
| SCHEMBL1881126 | 0.60 | ABCG2 (0.32) | ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130189373-A1 | Method of Treating Cancer Using Combination of a Bifunctional Alkylating Agent and DNA Repair Inhibitors | Academai Sinica (TW) | 2013-07-25 | — | — | US | claimed |
| WO-2011056663-A1 | METHOD OF TREATING CANCER USING COMBINATION OF A BIFUNCTIONAL ALKYLATING AGENT AND DNA REPAIR INHIBITORS | ACADEMIA SINICA (TW) | 2011-05-12 | — | — | WO | claimed |
| EP-0118566-B1 | INDENO[1,2-b]PYRROLE DERIVATIVES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1987-03-04 | — | — | EP | claimed |
| US-4578397-A | ANTICONVULSANTS, ANTIEPILEPTIC AGENTS, ANTIANXIETY AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1986-03-25 | — | — | US | claimed |
| EP-0118566-A1 | INDENO[1,2-b]PYRROLE DERIVATIVES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1984-09-19 | — | — | EP | claimed |
| JP-59046269-A | — | — | None | — | — | JP | disclosed |
| EP-3860712-A1 | MODULATORS OF ALPHA-1 ANTITRYPSIN | Vertex Pharmaceuticals Incorporated (US) | 2021-08-11 | — | — | EP | disclosed |
| WO-2020081257-A1 | MODULATORS OF ALPHA-1 ANTITRYPSIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-04-23 | — | — | WO | disclosed |
| US-8772284-B2 | Method of treating cancer using combination of a bifunctional alkylating agent and DNA repair inhibitors | ACADEMIA SINICA (TW) | 2014-07-08 | — | — | US | disclosed |
| US-8703951-B2 | Synthesis of 4H-benzo[D]pyrrolo[1,2-A]thiazoles and indolizino[6,7-b]indole derivatives and their use as antitumor therapeutic agents | ACADEMIA SINICA (TW) | 2014-04-22 | — | — | US | disclosed |
| US-20130189373-A1 | Method of Treating Cancer Using Combination of a Bifunctional Alkylating Agent and DNA Repair Inhibitors | Academai Sinica (TW) | 2013-07-25 | — | — | US | disclosed |
| US-20130178629-A1 | SYNTHESIS OF 4H-BENZO[D]PYRROLO[1,2-A]THIAZOLES AND INDOLIZINO[6,7-b]INDOLE DERIVATIVES AND THEIR USE AS ANTITUMOR THERAPEUTIC AGENTS | ACADEMIA SINICA (TW) | 2013-07-11 | — | — | US | disclosed |
| US-5574060-A | INDANOPYRROLES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0713484-A1 | INHIBITORS OF BIOGENIC AMINE TRANSPORTERS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1996-05-29 | — | — | EP | disclosed |
| WO-1995005364-A2 | INHIBITORS OF BIOGENIC AMINE TRANSPORTERS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1995-02-23 | — | — | WO | disclosed |
| EP-0569457-A1 | USE OF THIAZOLO- 2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO- 2,3-A]ISOINDOLE DERIVATIVES. | BOEHRINGER MANNHEIM GMBH (DE) | 1993-11-18 | — | — | EP | disclosed |
| US-4578397-A | ANTICONVULSANTS, ANTIEPILEPTIC AGENTS, ANTIANXIETY AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1986-03-25 | — | — | US | disclosed |
| US-4578397-A | ANTICONVULSANTS, ANTIEPILEPTIC AGENTS, ANTIANXIETY AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1986-03-25 | — | — | US | disclosed |
| EP-0118566-A1 | INDENO[1,2-b]PYRROLE DERIVATIVES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1984-09-19 | — | — | EP | disclosed |
| JP-S5946269-A | INDENO(1,2-B)PYRROLE DERIVATIVE | YOSHITOMI PHARMACEUT IND LTD | 1984-03-15 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178629-A1 | SYNTHESIS OF 4H-BENZO[D]PYRROLO[1,2-A]THIAZOLES AND INDOLIZINO[6,7-b]INDOLE DERIVATIVES AND THEIR USE AS ANTITUMOR THERAPEUTIC AGENTS | TOP2B, BRD4, MCL1 | ABCG2 468/4885 |
| US-20130189373-A1 | Method of Treating Cancer Using Combination of a Bifunctional Alkylating Agent and DNA Repair Inhibitors | TOP2A, UNG, MRE11 | ABCG2 394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.