Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.62 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HK1 | P19367 | 1/20 | 0.36 |
| ▸ | GALK1 | P51570 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30019213 | 1.00 | ABCG2 (0.62) | ABCG2IDO1MAPTALDH1A1MEN1 | |
| SCHEMBL7464999 | 0.85 | ABCG2 (0.55) | ABCG2IDO1MAPTALDH1A1MEN1 | |
| SCHEMBL4499072 | 0.83 | ABCG2 (0.46) | ABCG2IDO1MAPTALDH1A1MEN1 | |
| SCHEMBL4510312 | 0.82 | ABCG2 (0.45) | ABCG2IDO1MAPTALDH1A1MEN1 | |
| SCHEMBL7733305 | 0.80 | ABCG2 (0.50) | ABCG2ALDH1A1TSHRHSD17B10MAPK1 | |
| SCHEMBL1820361 | 0.77 | ABCG2 (0.68) | ABCG2IDO1MAPTALDH1A1MEN1 | |
| SCHEMBL4313626 | 0.77 | ABCG2 (0.68) | ABCG2IDO1MAPTALDH1A1MEN1 | |
| SCHEMBL725971 | 0.77 | ABCG2 (0.51) | ABCG2IDO1 | |
| SCHEMBL1899423 | 0.77 | ABCG2 (0.68) | ABCG2IDO1MAPTALDH1A1MEN1 | |
| SCHEMBL527160 | 0.76 | ABCG2 (0.46) | ABCG2IDO1MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108503578-A | A kind of synthetic method of indeno-[1,2-b] indoles -10 (5H) -one class compound | 中国烟草总公司郑州烟草研究院 | 2018-09-07 | — | — | CN | claimed |
| US-20240392044-A1 | OLEFIN POLYMERIZATION CATALYST SYSTEM AND POLYMERIZATION PROCESS | NOVA CHEMICALS (INTERNATIONAL) S.A. (CH) | 2024-11-28 | — | — | US | disclosed |
| EP-4405367-A1 | OLEFIN POLYMERIZATION CATALYST SYSTEM AND POLYMERIZATION PROCESS | Nova Chemicals (International) S.A. (CH) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023042155-A1 | OLEFIN POLYMERIZATION CATALYST SYSTEM AND POLYMERIZATION PROCESS | NOVA CHEMICALS (INTERNATIONAL) S.A. (CH) | 2023-03-23 | — | — | WO | disclosed |
| CN-108503578-A | A kind of synthetic method of indeno-[1,2-b] indoles -10 (5H) -one class compound | 中国烟草总公司郑州烟草研究院 | 2018-09-07 | — | — | CN | disclosed |
| CN-108503578-A | A kind of synthetic method of indeno-[1,2-b] indoles -10 (5H) -one class compound | 中国烟草总公司郑州烟草研究院 | 2018-09-07 | — | — | CN | disclosed |
| JP-5371763-B2 | — | — | 2013-12-18 | — | — | JP | disclosed |
| EP-2079691-B1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOUR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | UNIV DUESSELDORF H HEINE (DE) | 2013-08-14 | — | — | EP | disclosed |
| US-8252814-B2 | Agents and crystals for improving excretory potency of urinary bladder | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-08-28 | — | — | US | disclosed |
| US-8133913-B2 | Substituted indeno [1,2-b]indole derivatives as novel inhibitors of protein kinase CK2 and their use as tumor therapeutic agents, cytostatics and diagnostic aids | Heinrich-Heine Universitat Dusseldof (DE) | 2012-03-13 | — | — | US | disclosed |
| US-6391902-B2 | TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION SUCH AS INCONTINENCE AND IRRITABLE BOWEL SYNDROME | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-21 | — | — | US | disclosed |
| US-6376629-B2 | ORGANOMETALLIC COMPOUND | EQUISTAR CHEMICALS, LP | 2002-04-23 | — | — | US | disclosed |
| US-20010047026-A1 | Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers | AMERICAN HOME PRODUCTS CORPORATION | 2001-11-29 | — | — | US | disclosed |
| US-6288099-B1 | COMPOUNDS SUCH AS 8-BROMO-10H-BENZO(4,5)FURO(3,2-B)INDOLE-1-CARBOXYLIC ACID USED TO TREAT DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRATION SUCH AS URINARY INCONTINENCE AND IRRITABLE BOWL SYNDROME | AMERICAN HOME PRODUCTS CORPORATION | 2001-09-11 | — | — | US | disclosed |
| EP-1118322-A1 | DRUGS FOR IMPROVING VESICAL EXCRETORY STRENGTH | Takeda Chemical Industries, Ltd. (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-20010007848-A1 | Single-site catalysts for olefin polymerization | EQUISTAR CHEMICALS, L.P. | 2001-07-12 | — | — | US | disclosed |
| US-6232260-B1 | ORGANOMETALLIC COMPLEX COMPRISES A GROUP 3 TO 10 TRANSITION OR LANTHANIDE METAL, M, AND AT LEAST ONE INDENOINDOLYL LIGAND THAT IS .PI.-BONDED TO M. | EQUISTAR CHEMICALS, L.P. | 2001-05-15 | — | — | US | disclosed |
| WO-2001027125-A1 | SINGLE-SITE CATALYSTS FOR OLEFIN POLYMERIZATION | EQUISTAR CHEMICALS, L.P. (US) | 2001-04-19 | — | — | WO | disclosed |
| US-5620973-A | CHOLINESTERASE INHIBITOR; ALZHEIMER*S DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0655451-A1 | Tetracyclic condensed heterocyclic compounds for the treatment of senile dementia | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010047026-A1 | Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers | KCNJ2, KCNN3, KCNN2 | ABCG2 904/4885IDO1 1016/4885MAPT 4000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.