Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KLK3 | P07288 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18645722 | 0.85 | L3MBTL1 (0.49) | L3MBTL1GAATAS1R3TAS1R1RAB9A | |
| SCHEMBL18644549 | 0.83 | GAA (0.50) | L3MBTL1GAATAS1R3TAS1R1RAB9A | |
| SCHEMBL20482131 | 0.83 | RAB9A (0.56) | L3MBTL1GAATAS1R3TAS1R1RAB9A | |
| SCHEMBL701884 | 0.79 | TDP1 (0.54) | L3MBTL1GAATAS1R3TAS1R1RAB9A | |
| SCHEMBL30041235 | 0.79 | TDP1 (0.54) | L3MBTL1GAATAS1R3TAS1R1RAB9A | |
| SCHEMBL18644553 | 0.78 | L3MBTL1 (0.49) | L3MBTL1GAATAS1R3TAS1R1RAB9A | |
| SCHEMBL13356595 | 0.78 | RAB9A (0.51) | L3MBTL1GAATAS1R3TAS1R1RAB9A | |
| SCHEMBL9181228 | 0.76 | TAS1R3 (0.58) | L3MBTL1GAATAS1R3TAS1R1RAB9A | |
| SCHEMBL27326882 | 0.76 | TAS1R3 (0.58) | L3MBTL1TAS1R3TAS1R1RAB9ANPC1 | |
| SCHEMBL1192488 | 0.74 | ESR1 (0.58) | L3MBTL1GAATAS1R3TAS1R1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017042182-A1 | TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2017-03-16 | — | — | WO | disclosed |