Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19588492 | 0.80 | SMN1; SMN2 (0.66) | LMNAALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL21667414 | 0.79 | SMN1; SMN2 (0.65) | LMNAALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL18648916 | 0.77 | SMN1; SMN2 (0.68) | LMNAALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL9818019 | 0.77 | IDO1 (0.61) | LMNAALDH1A1 | |
| SCHEMBL30293265 | 0.74 | BRD4 (0.57) | ALDH1A1BRD4CREBBPTP53MAOA | |
| SCHEMBL28978985 | 0.74 | CREBBP (0.50) | LMNANPC1ALDH1A1BRD4CREBBP | |
| SCHEMBL30293263 | 0.74 | CREBBP (0.50) | LMNANPC1ALDH1A1BRD4CREBBP | |
| SCHEMBL10280619 | 0.73 | ALDH1A1 (0.50) | LMNANPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL14047506 | 0.71 | TP53 (0.51) | LMNAALDH1A1KMT2ATSHRMAPT | |
| SCHEMBL12698422 | 0.70 | TSHR (0.69) | LMNAALDH1A1MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9802948-B2 | Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics | TRUSTEES OF BOSTON UNIVERISTY (US) | 2017-10-31 | — | — | US | disclosed |
| US-9597325-B2 | Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics | TRUSTEES OF BOSTON UNIVERSITY (US) | 2017-03-21 | — | — | US | disclosed |