SCHEMBL28978985

SCHEMBL28978985

O=C1CC(F)c2cc(O)ccc2N1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 4/20 0.50
BRD4 O60885 4/20 0.50
MAOA P21397 1/20 0.46
MAOB P27338 1/20 0.46
ALDH1A1 P00352 5/20 0.41
HPGD P15428 4/20 0.36
GAA P10253 1/20 0.36
HSD17B10 Q99714 1/20 0.36
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA4 P22748 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
GLA P06280 1/20 0.35
CHRNB2 P17787 1/20 0.34
CHRNA4 P43681 1/20 0.34
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
MAPT P10636 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30293263 1.00 CREBBP (0.50) CREBBPBRD4MAOAMAOBALDH1A1
SCHEMBL14188942 0.87 BRD4 (0.47) CREBBPBRD4MAOAMAOBALDH1A1
SCHEMBL30293265 0.80 BRD4 (0.57) CREBBPBRD4MAOAMAOBALDH1A1
SCHEMBL18648917 0.74 LMNA (0.46) CREBBPBRD4MAOAMAOBALDH1A1
SCHEMBL20715625 0.70 CREBBP (0.54) CREBBPBRD4MAOAMAOBTP53
SCHEMBL28979236 0.70 MAOA (0.42) CREBBPBRD4MAOAMAOBHSD17B10
SCHEMBL30293235 0.70 MAOA (0.42) CREBBPBRD4MAOAMAOBHSD17B10
SCHEMBL17673137 0.69 CREBBP (0.63) CREBBPBRD4MAOAMAOBEP300
SCHEMBL19518213 0.69 CREBBP (0.63) CREBBPBRD4MAOAMAOBEP300
SCHEMBL31734649 0.67 MAOA (0.55) CREBBPBRD4MAOAMAOBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109988093-B Amine compound for inhibiting SSAO/VAP-1 and application thereof in medicine 广东东阳光药业有限公司 2023-04-07 CN disclosed