Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.53 |
| ▸ | CDK1 | P06493 | 13/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.53 |
| ▸ | CDK9 | P50750 | 9/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.53 |
| ▸ | FLT3 | P36888 | 3/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.53 |
| ▸ | CCND3 | P30281 | 1/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 7/20 | 0.52 |
| ▸ | AURKA | O14965 | 5/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 5/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.52 |
| ▸ | JAK2 | O60674 | 4/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571737 | 0.87 | CA2 (0.52) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL1873284 | 0.82 | PTK2 (0.47) | JAK3AURKAAURKBJAK2RET | |
| SCHEMBL1868898 | 0.81 | BRAF (0.45) | CDK2CDK1CCNB1CDK5CCNE1 | |
| SCHEMBL1871204 | 0.80 | NEK2 (0.51) | AURKASYKCSNK2A1ALKNEK2 | |
| SCHEMBL1474463 | 0.80 | JAK3 (0.65) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL1474986 | 0.79 | JAK3 (0.69) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL12671410 | 0.76 | MAP3K5 (0.42) | CDK2CDK5FLT3CDK5R1JAK3 | |
| SCHEMBL1633964 | 0.76 | SYK (0.57) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL3647900 | 0.75 | SYK (0.46) | FLT3KDRSYKCSNK2A1EGFR | |
| SCHEMBL1868651 | 0.75 | CAMK2D (0.44) | CDK2CDK5CCNA2CDK5R1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079988-A9 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS AG (CH) | 2011-05-12 | — | — | WO | claimed |
| US-20100216767-A1 | QUINAZOLINES FOR PDK1 INHIBITION | AIKAWA MINA | 2010-08-26 | — | — | US | claimed |
| WO-2008079988-A9 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS AG (CH) | 2011-05-12 | — | — | WO | disclosed |
| US-20100216767-A1 | QUINAZOLINES FOR PDK1 INHIBITION | AIKAWA MINA | 2010-08-26 | — | — | US | disclosed |
| US-20100216767-A1 | QUINAZOLINES FOR PDK1 INHIBITION | AIKAWA MINA | 2010-08-26 | — | — | US | disclosed |
| US-20100216767-A1 | QUINAZOLINES FOR PDK1 INHIBITION | AIKAWA MINA | 2010-08-26 | — | — | US | disclosed |
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | JAIN RAMA | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216767-A1 | QUINAZOLINES FOR PDK1 INHIBITION | PDK1, PDK2, PDK3 | CDK2 39/4885CDK1 75/4885CCNT1 1008/4885 |
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | PDK1, PDK2, PDK3 | CDK2 11/4885CDK1 15/4885CCNT1 406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.