Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 5/20 | 0.35 |
| ▸ | MMP2 | P08253 | 4/20 | 0.35 |
| ▸ | MMP14 | P50281 | 3/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654484 | 0.79 | SIRT5 (0.44) | KDM4EMAPTALDH1A1HPGDRAB9A | |
| SCHEMBL21880076 | 0.77 | KDM4E (0.42) | KDM4EMAPTALDH1A1HPGDRAB9A | |
| SCHEMBL18654619 | 0.73 | KMT2A (0.35) | KDM4EMAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL18626491 | 0.72 | ALOX15 (0.47) | KDM4EMAPTALDH1A1HPGDRAB9A | |
| SCHEMBL8818379 | 0.72 | ALDH1A1 (0.47) | KDM4EMAPTALDH1A1HPGDRAB9A | |
| SCHEMBL1437509 | 0.69 | KDM4E (0.44) | KDM4EMAPTALDH1A1HPGDRAB9A | |
| SCHEMBL21238310 | 0.69 | KDM4E (0.44) | KDM4EMAPTALDH1A1HPGDRAB9A | |
| SCHEMBL20534000 | 0.69 | KDM4E (0.45) | KDM4EMAPTALDH1A1HPGDRAB9A | |
| SCHEMBL369489 | 0.69 | ALDH1A1 (0.49) | KDM4EMAPTALDH1A1HPGDRAB9A | |
| SCHEMBL1437518 | 0.68 | ALDH1A1 (0.42) | KDM4EMAPTALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |