Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654743 | 0.91 | MAPT (0.36) | MAPTTP53KDM4EHDAC1ATR | |
| SCHEMBL18654802 | 0.89 | ADORA2A (0.36) | MAPTTP53KDM4EKMT2AMEN1 | |
| SCHEMBL18654797 | 0.89 | MAPT (0.37) | MAPTTP53KDM4EKMT2AMEN1 | |
| SCHEMBL18654629 | 0.89 | MAPT (0.39) | MAPTTP53KMT2ANTRK1MEN1 | |
| SCHEMBL18654415 | 0.87 | TP53 (0.36) | TP53CHRM4HDAC1ATRNTRK1 | |
| SCHEMBL18654323 | 0.82 | NTRK1 (0.35) | TP53CHRM4HDAC1ATRNTRK1 | |
| SCHEMBL18655158 | 0.82 | TP53 (0.42) | MAPTTP53KDM4EALDH1A1 | |
| SCHEMBL18654738 | 0.82 | FYN (0.47) | — | |
| SCHEMBL14897358 | 0.81 | F2 (0.34) | MAPTTP53KDM4EKMT2ACHRM4 | |
| SCHEMBL14897685 | 0.80 | HTR2A (0.36) | MAPTTP53KDM4EKMT2ACHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |