Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654802 | 0.91 | ADORA2A (0.36) | MAPTTP53ALDH1A1KDM4EMEN1 | |
| SCHEMBL18654739 | 0.90 | POLB (0.35) | MAPTTP53ALDH1A1KDM4ETGFBR1 | |
| SCHEMBL18654741 | 0.89 | MAPT (0.35) | MAPTTP53ALDH1A1KDM4EMEN1 | |
| SCHEMBL18654629 | 0.88 | MAPT (0.39) | MAPTTP53MEN1KMT2A | |
| SCHEMBL18655158 | 0.84 | TP53 (0.42) | MAPTTP53ALDH1A1KDM4ENPSR1 | |
| SCHEMBL18655200 | 0.83 | MAPT (0.37) | MAPTTP53ALDH1A1KDM4EMEN1 | |
| SCHEMBL18655240 | 0.81 | CSNK1D (0.36) | MAPTALDH1A1KDM4EUSP2POLB | |
| SCHEMBL18654738 | 0.81 | FYN (0.47) | — | |
| SCHEMBL18654743 | 0.79 | MAPT (0.36) | MAPTTP53ALDH1A1KDM4ETDP1 | |
| SCHEMBL14897343 | 0.79 | MAPT (0.36) | MAPTTP53ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |