Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 11/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654740 | 0.91 | RIPK1 (0.40) | MAPTTP53RIPK1NTRK1 | |
| SCHEMBL18654741 | 0.89 | MAPT (0.35) | MAPTTP53NTRK1MEN1KMT2A | |
| SCHEMBL18654742 | 0.89 | RIPK1 (0.40) | RIPK1NTRK1SCN9A | |
| SCHEMBL18654802 | 0.88 | ADORA2A (0.36) | MAPTTP53MEN1KMT2A | |
| SCHEMBL18654797 | 0.88 | MAPT (0.37) | MAPTTP53MEN1KMT2A | |
| SCHEMBL18654738 | 0.85 | FYN (0.47) | RIPK1 | |
| SCHEMBL18654863 | 0.84 | RIPK1 (0.37) | RIPK1NTRK1SCN9A | |
| SCHEMBL14896733 | 0.81 | RIPK1 (0.40) | MAPTTP53RIPK1RORCSCN9A | |
| SCHEMBL18655158 | 0.81 | TP53 (0.42) | MAPTTP53 | |
| SCHEMBL18654743 | 0.80 | MAPT (0.36) | MAPTTP53RIPK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |