Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654741 | 0.91 | MAPT (0.35) | MAPTNTRK1ATRTP53HDAC1 | |
| SCHEMBL18654415 | 0.90 | TP53 (0.36) | NTRK1ATRTP53HDAC1CSNK1D | |
| SCHEMBL18655240 | 0.89 | CSNK1D (0.36) | MAPTCSNK1DCSNK1EKDM4EALDH1A1 | |
| SCHEMBL18654739 | 0.89 | POLB (0.35) | MAPTTP53CSNK1DCSNK1EKDM4E | |
| SCHEMBL18654740 | 0.88 | RIPK1 (0.40) | MAPTNTRK1TP53KDM4EFYN | |
| SCHEMBL18654429 | 0.87 | EPHB3 (0.39) | MAPTTP53CSNK1DCSNK1EALDH1A1 | |
| SCHEMBL18655200 | 0.87 | MAPT (0.37) | MAPTTP53CSNK1DCSNK1EKDM4E | |
| SCHEMBL18654323 | 0.84 | NTRK1 (0.35) | NTRK1ATRTP53HDAC1CSNK1D | |
| SCHEMBL18654986 | 0.81 | MAPT (0.43) | MAPTTP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL18654725 | 0.81 | DYRK1A (0.51) | FYNRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |