Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.36 |
| ▸ | MMP9 | P14780 | 8/20 | 0.36 |
| ▸ | MMP8 | P22894 | 6/20 | 0.36 |
| ▸ | MMP1 | P03956 | 8/20 | 0.34 |
| ▸ | MMP3 | P08254 | 7/20 | 0.34 |
| ▸ | MMP13 | P45452 | 3/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.33 |
| ▸ | MMP7 | P09237 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | MMP14 | P50281 | 2/20 | 0.33 |
| ▸ | MMP20 | O60882 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | MMP10 | P09238 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP15 | P51511 | 1/20 | 0.33 |
| ▸ | MMP16 | P51512 | 1/20 | 0.33 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.33 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | MMP24 | Q9Y5R2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20259542 | 0.78 | USP2 (0.36) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL15314107 | 0.78 | USP2 (0.36) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL13114608 | 0.78 | USP2 (0.36) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL16418389 | 0.76 | MMP1 (0.49) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL19156077 | 0.76 | ALDH1A1 (0.46) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL24920451 | 0.76 | KISS1R (0.38) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL18638424 | 0.74 | CA1 (0.49) | MMP2MMP9MMP1MMP3MMP7 | |
| SCHEMBL21566764 | 0.74 | ECE1 (0.46) | MMP2MMP1MMP3MMP7ECE1 | |
| SCHEMBL24655789 | 0.74 | MMP2 (0.37) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL13501731 | 0.74 | CA1 (0.49) | MMP2MMP9MMP1MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969710-B2 | Heteroaryl compounds as IRAK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2018-05-15 | — | — | US | disclosed |
| US-20170081307-A1 | HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170081307-A1 | HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | MMP2 3930/4885MMP9 3624/4885MMP8 3174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.