Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 7/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18664403 | 0.89 | MMP3 (0.57) | MMP3CA12CA2CA3CA6 | |
| SCHEMBL17643479 | 0.85 | AHR (0.47) | EGLN2CYP11B1CYP11B2MAOADGAT1 | |
| SCHEMBL17629881 | 0.82 | MAOB (0.43) | AREGLN2CYP11B1CYP11B2KDM1A | |
| SCHEMBL17629942 | 0.82 | EGLN2 (0.49) | AREGLN2CYP11B1CYP11B2KDM1A | |
| SCHEMBL28022390 | 0.81 | CSNK2A1 (0.49) | CA2AREGLN2CYP11B1CYP11B2 | |
| SCHEMBL17629878 | 0.81 | ENPP2 (0.56) | MMP3CA2AREGLN2CYP11B1 | |
| SCHEMBL9348873 | 0.80 | CYP11B1 (0.53) | CA12CA2CA3CA6CA9 | |
| SCHEMBL4667162 | 0.80 | ESR2 (0.59) | MMP3CA12CA2CA3CA6 | |
| SCHEMBL31463157 | 0.79 | MMP3 (0.47) | MMP3CA12CA2CA9CYP11B2 | |
| SCHEMBL2786090 | 0.79 | MMP3 (0.57) | MMP3CA12CA2CA3CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11447501-B2 | Biphenyl-containing diarylpyrimido compounds, pharmaceutically-acceptable salts thereof, composition and preparation thereof | Fudan Univeristy (CN) | 2022-09-20 | — | — | US | disclosed |
| EP-3349581-B1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES INC (US) | 2021-12-01 | — | — | EP | disclosed |
| EP-3349581-B1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES INC (US) | 2021-12-01 | — | — | EP | disclosed |
| US-20210040109-A1 | BIPHENYL-CONTAINING DIARYLPYRIMIDO COMPOUNDS, PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF, COMPOSITION AND PREPARATION THEREOF | FUDAN UNIVERSITY (CN) | 2021-02-11 | — | — | US | disclosed |
| US-10766890-B2 | Hepatitis B core protein modulators | ASSEMBLY BIOSCIENCES, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-10766890-B2 | Hepatitis B core protein modulators | ASSEMBLY BIOSCIENCES, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-20180265484-A1 | HEPATITIS B CORE PROTEIN MODULATORS | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-09-20 | — | — | US | disclosed |
| WO-2017048962-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES, INC. (US) | 2017-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040109-A1 | BIPHENYL-CONTAINING DIARYLPYRIMIDO COMPOUNDS, PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF, COMPOSITION AND PREPARATION THEREOF | CYP2C19, CYP2C9, CYP2B6 | MMP3 4585/4885CA12 3025/4885CA2 1989/4885 |
| US-20180265484-A1 | HEPATITIS B CORE PROTEIN MODULATORS | HAVCR2, FABP1, MAVS | MMP3 4619/4885CA12 3562/4885CA2 4707/4885 |
| US-11447501-B2 | Biphenyl-containing diarylpyrimido compounds, pharmaceutically-acceptable salts thereof, composition and preparation thereof | CYP2C19, CYP2C9, CYP2B6 | MMP3 4585/4885CA12 3025/4885CA2 1989/4885 |
| US-10766890-B2 | Hepatitis B core protein modulators | HAVCR2, FABP1, MAVS | MMP3 4619/4885CA12 3562/4885CA2 4707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.