Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.57 |
| ▸ | FEN1 | P39748 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.44 |
| ▸ | BCL9 | O00512 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | KAT7 | O95251 | 1/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1866539 | 1.00 | ALOX5AP (0.57) | ALOX5APFEN1MAPTNPSR1SCN9A | |
| SCHEMBL1869732 | 0.83 | ALOX5AP (0.47) | ALOX5APFEN1MAPTSCN9AGPR119 | |
| SCHEMBL1869734 | 0.83 | ALOX5AP (0.47) | ALOX5APFEN1MAPTSCN9AGPR119 | |
| SCHEMBL3323442 | 0.83 | FEN1 (0.56) | ALOX5APFEN1SCN9AGPR119ACKR3 | |
| SCHEMBL3323433 | 0.83 | FEN1 (0.56) | ALOX5APFEN1SCN9AGPR119ACKR3 | |
| SCHEMBL3326969 | 0.82 | ALOX5AP (0.57) | ALOX5APFEN1SCN9AGPR119ACKR3 | |
| SCHEMBL3326965 | 0.82 | ALOX5AP (0.57) | ALOX5APFEN1SCN9AGPR119ACKR3 | |
| SCHEMBL12631899 | 0.78 | REN (0.46) | ALOX5APFEN1 | |
| SCHEMBL9996326 | 0.78 | SCN9A (0.59) | ALOX5APFEN1SCN9AGPR119ACKR3 | |
| SCHEMBL7710276 | 0.77 | HPGDS (0.49) | ALOX5APFEN1SCN9AGPR119TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455521-B2 | Diaminoalkane aspartic protease inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20110105506-A1 | Diaminoalkane aspartic protease inhibitors | VITAE PHARMACEUTICALS, INC. | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105506-A1 | Diaminoalkane aspartic protease inhibitors | DNPEP, PEPD, ACE | ALOX5AP 1785/4885FEN1 1512/4885MAPT 1603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.