Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | ESRRB | O95718 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | ESRRA | P11474 | 1/20 | 0.56 |
| ▸ | ESRRG | P62508 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13757748 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2AMEN1CYP2C19HTT | |
| SCHEMBL3486845 | 0.84 | GPR119 (0.69) | SMN1; SMN2KMT2AMEN1CYP2C19HTT | |
| SCHEMBL20423694 | 0.83 | KMT2A (0.68) | SMN1; SMN2KMT2AMEN1CYP2C19HTT | |
| SCHEMBL24619971 | 0.83 | KMT2A (0.68) | SMN1; SMN2KMT2AMEN1CYP2C19HTT | |
| SCHEMBL24620293 | 0.83 | SMN1; SMN2 (0.68) | SMN1; SMN2KMT2AMEN1CYP2C19HTT | |
| SCHEMBL11889675 | 0.83 | SMN1; SMN2 (0.68) | SMN1; SMN2KMT2AMEN1CYP2C19HTT | |
| SCHEMBL18641168 | 0.82 | ALDH1A1 (0.49) | SMN1; SMN2HTTMAPTLMNAALDH1A1 | |
| SCHEMBL18641154 | 0.82 | DRD2 (0.52) | MAPTALDH1A1GFER | |
| SCHEMBL4503214 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2KMT2AMEN1CYP2C19HTT | |
| SCHEMBL5573222 | 0.80 | MAPT (0.76) | SMN1; SMN2KMT2AMEN1CYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017045750-A1 | COMPOUNDS AS ASIC INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-03-23 | — | — | WO | disclosed |