SCHEMBL1866946

SCHEMBL1866946

C=C(C)C(=O)Nc1ccccc1OC(=O)OC(C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.45
MAPT P10636 1/20 0.41
POLB P06746 4/20 0.41
TDP1 Q9NUW8 3/20 0.41
CASP6 P55212 1/20 0.41
KMT2A Q03164 2/20 0.40
BRD4 O60885 1/20 0.40
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
L3MBTL1 Q9Y468 3/20 0.39
ALDH1A1 P00352 3/20 0.38
HPGD P15428 1/20 0.38
PDK1 Q15118 1/20 0.38
PDK2 Q15119 1/20 0.38
PDK3 Q15120 1/20 0.38
PDK4 Q16654 1/20 0.38
ELANE P08246 1/20 0.38
KDM4E B2RXH2 3/20 0.37
LMNA P02545 1/20 0.37
ALOX12 P18054 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1863718 0.82 TDP1 (0.48) HSD17B10MAPTPOLBTDP1CASP6
SCHEMBL13756066 0.82 HSD17B10 (0.43) HSD17B10MAPTPOLBTDP1CASP6
SCHEMBL1858242 0.81 MAPK3 (0.46) HSD17B10MAPTKMT2AALDH1A1PDK1
SCHEMBL8370955 0.79 ELANE (0.44) HSD17B10TDP1KMT2ABRD4NPC1
SCHEMBL8478426 0.78 HSD17B10 (0.45) HSD17B10MAPTPOLBKMT2ABRD4
SCHEMBL9187080 0.77 MTNR1A (0.41) MAPTKMT2ANPC1RAB9AALDH1A1
SCHEMBL8477021 0.77 POLB (0.63) HSD17B10MAPTPOLBTDP1CASP6
SCHEMBL10027967 0.77 LMNA (0.49) HSD17B10POLBKMT2ABRD4NPC1
SCHEMBL9185888 0.76 TDP1 (0.54) MAPTPOLBTDP1KMT2ANPC1
SCHEMBL29395702 0.75 TDP1 (0.46) HSD17B10MAPTPOLBTDP1CASP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7939241-B2 (Meth)acrylamide derivative, polymer, chemically amplified photosensitive resin composition, and patterning method NEC CORPORATION (JP) 2011-05-10 US disclosed
US-7939241-B2 (Meth)acrylamide derivative, polymer, chemically amplified photosensitive resin composition, and patterning method NEC CORPORATION (JP) 2011-05-10 US disclosed
US-20090068587-A1 (Meth) acrylamide derivative, polymer, chemically amplified photosensitive resin composition, and patterning method NEC CORPORATION (JP) 2009-03-12 US disclosed
US-20090068587-A1 (Meth) acrylamide derivative, polymer, chemically amplified photosensitive resin composition, and patterning method NEC CORPORATION (JP) 2009-03-12 US disclosed
EP-0519297-B1 Radiation-sensitive composition comprising as binders novel polymers with units derived from amides of alpha,beta-unsaturated carboxylic acids HOECHST AG (DE) 1995-09-20 EP disclosed
US-5326840-A Radiation-sensitive mixture containing novel polymers embodying units composed of amides of α, β-unsaturated carboxylic acids as binders HOECHST AKTIENGESELLSCHAFT (DE) 1994-07-05 US disclosed
EP-0519297-A2 Radiation-sensitive composition comprising as binders novel polymers with units derived from amides of alpha,beta-unsaturated carboxylic acids HOECHST AKTIENGESELLSCHAFT (DE) 1992-12-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090068587-A1 (Meth) acrylamide derivative, polymer, chemically amplified photosensitive resin composition, and patterning method MMAB, DNMT3A, MAT1A HSD17B10 2926/4885MAPT 1386/4885POLB 672/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.