Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.36 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.36 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.36 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21677304 | 1.00 | LMNA (0.40) | LMNAPOLBCTSSCTSKAKT1 | |
| SCHEMBL21677273 | 0.89 | NLRP3 (0.42) | LMNAPOLBCTSSCTSKAKT1 | |
| SCHEMBL4665018 | 0.84 | LMNA (0.39) | LMNAPOLBCTSSCTSKAKT1 | |
| SCHEMBL4665019 | 0.84 | AKT1 (0.39) | LMNAPOLBCTSSCTSKAKT1 | |
| SCHEMBL31486571 | 0.78 | AAK1 (0.32) | LMNAPOLBAKT1MTNR1AMTNR1B | |
| SCHEMBL31486781 | 0.78 | DRD2 (0.32) | LMNAPOLBAAK1CA12CA14 | |
| SCHEMBL31486754 | 0.77 | SMN1; SMN2 (0.36) | POLBCTSSCTSKAAK1SMN1; SMN2 | |
| SCHEMBL18683500 | 0.75 | LMNA (0.39) | LMNAPOLBCTSSCTSKAKT1 | |
| SCHEMBL20349827 | 0.75 | BACE1 (0.40) | LMNAGUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL18683050 | 0.74 | LMNA (0.38) | LMNAPOLBCTSSCTSKAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017050978-A1 | 2,3,4,5-TETRAHYDROPYRIDIN-6-AMINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-30 | — | — | WO | disclosed |