Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.34 |
| ▸ | CFB | P00751 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15590153 | 0.87 | CFB (0.39) | P2RX7MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL31136010 | 0.84 | CFB (0.45) | P2RX7KMT2AALDH1A1CFBTRIM24 | |
| SCHEMBL16400704 | 0.84 | CFB (0.45) | P2RX7KMT2AALDH1A1CFBTRIM24 | |
| SCHEMBL18683282 | 0.78 | TRIM24 (0.34) | CFBTRIM24TRIM33 | |
| SCHEMBL20939366 | 0.77 | P2RX7 (0.42) | P2RX7MAPTKMT2AAURKATPX2 | |
| SCHEMBL15590525 | 0.74 | CFB (0.39) | P2RX7MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL15589671 | 0.73 | CFB (0.43) | P2RX7KMT2AALDH1A1CFBTRIM24 | |
| SCHEMBL23916844 | 0.72 | P2RX7 (0.36) | P2RX7MAPTKMT2AAURKATPX2 | |
| SCHEMBL15590276 | 0.72 | CFB (0.41) | P2RX7KMT2ACFBTRIM24TRIM33 | |
| SCHEMBL3269246 | 0.72 | ALDH1A1 (0.43) | MAPTKMT2AALDH1A1MEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855456-B1 | COMPLEMENT PATHWAY MODULATORS AND USES THEREOF | NOVARTIS AG (CH) | 2017-03-29 | — | — | EP | disclosed |