Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2126704 | 0.86 | KDM4E (0.38) | LMNANPSR1SMN1; SMN2CSNK2A1MET | |
| SCHEMBL2123839 | 0.85 | IMPDH2 (0.38) | LMNATSHRNPSR1SMN1; SMN2MET | |
| SCHEMBL2124306 | 0.84 | CSNK2A1 (0.37) | CSNK2A1HSD17B10ADORA2AADORA1MAP2K1 | |
| SCHEMBL2124785 | 0.83 | BRAF (0.46) | LMNACSNK2A1METKDRALDH1A1 | |
| SCHEMBL18686163 | 0.81 | NPC1 (0.37) | GAASMN1; SMN2CSNK2A1METKDR | |
| SCHEMBL2125785 | 0.81 | EGFR (0.43) | CSNK2A1ADORA2AADORA1MAP2K1TUBB4A | |
| SCHEMBL2124727 | 0.81 | SRC (0.44) | CSNK2A1ADORA1TUBB4ATUBBTUBA3C | |
| SCHEMBL2122690 | 0.81 | LMNA (0.43) | LMNASMN1; SMN2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL2127740 | 0.80 | ROCK2 (0.40) | LMNASMN1; SMN2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL2125749 | 0.80 | ROCK2 (0.40) | LMNASMN1; SMN2ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443123-B1 | SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | RIGEL PHARMACEUTICALS INC (US) | 2017-04-05 | — | — | EP | claimed |