Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 2/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573351 | 0.79 | CYP1A2 (0.49) | SMN1; SMN2TDP1TSHRL3MBTL1MEN1 | |
| SCHEMBL4076707 | 0.72 | GPR35 (0.44) | SMN1; SMN2TDP1TSHRL3MBTL1MEN1 | |
| SCHEMBL4076713 | 0.72 | GPR35 (0.44) | SMN1; SMN2TDP1TSHRL3MBTL1MEN1 | |
| SCHEMBL1205554 | 0.72 | TP53 (0.47) | SMN1; SMN2L3MBTL1MEN1KMT2AGRM8 | |
| SCHEMBL3131921 | 0.71 | ALDH1A1 (0.44) | SMN1; SMN2TDP1TSHRL3MBTL1MEN1 | |
| SCHEMBL7266502 | 0.70 | AKR1C3 (0.44) | TDP1MEN1KMT2ANPC1AKR1C3 | |
| Propionic Acid SCHEMBL10982295 | 0.70 | MEN1 (0.47) | SMN1; SMN2TDP1TSHRL3MBTL1MEN1 | |
| SCHEMBL14200052 | 0.70 | TDP1 (0.48) | SMN1; SMN2TDP1TSHRL3MBTL1MEN1 | |
| SCHEMBL13070858 | 0.69 | GPR35 (0.44) | SMN1; SMN2TDP1TSHRMEN1KMT2A | |
| SCHEMBL9054626 | 0.69 | KDM4E (0.43) | SMN1; SMN2TSHRL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2701512-B1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-04-05 | — | — | EP | disclosed |