SCHEMBL18692001

SCHEMBL18692001

C[Si](C)(O)c1ccc(-c2ccc([Si](C)(C)O)cc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NR1I2 O75469 9/20 0.39
ESR1 P03372 4/20 0.35
ESR2 Q92731 2/20 0.35
RORA P35398 1/20 0.33
RORC P51449 1/20 0.33
RORB Q92753 1/20 0.33
NR1H4 Q96RI1 1/20 0.33
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
KMT2A Q03164 1/20 0.33
HPGD P15428 1/20 0.33
NR1H2 P55055 2/20 0.31
NR1H3 Q13133 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL235602 0.90 NR1I2 (0.43) NR1I2ESR1ESR2RORARORC
SCHEMBL27043326 0.87 ALDH1A1 (0.52) MEN1NPC1RAB9AKMT2AHPGD
SCHEMBL7902561 0.87 NR1I2 (0.42) NR1I2ESR1ESR2RORARORC
SCHEMBL27043252 0.82 NR1I2 (0.32) NR1I2
SCHEMBL29086820 0.81 NR1I2 (0.39) NR1I2ESR1ESR2RORARORC
SCHEMBL29242328 0.81 ESR1 (0.50) NR1I2ESR1ESR2RORARORC
SCHEMBL11979357 0.81 NR1H2 (0.46) NR1I2ESR1ESR2RORARORC
SCHEMBL6433024 0.81 ESR1 (0.35) ESR1ESR2HPGDNR1H2NR1H3
SCHEMBL18691997 0.79 ESR1 (0.54) NR1I2ESR1ESR2MEN1NPC1
SCHEMBL3482615 0.79 ACHE (0.47) NR1I2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3581607-B1 NOVEL MESOGEN-SILICON COMPOUND (CO)POLYMER AND THERMOPLASTIC ELASTOMER SHINETSU CHEMICAL CO (JP) 2022-04-20 EP disclosed
US-11142612-B2 Mesogen-silicon compound (co)polymer and thermoplastic elastomer SHIN-ETSU CHEMICAL CO., LTD. (JP) 2021-10-12 US disclosed
US-10723845-B2 Process for preparing linear carbosiloxane polymers DOW SILICONES CORPORATION (US) 2020-07-28 US disclosed
US-20200079911-A1 PROCESS FOR PREPARING LINEAR CARBOSILOXANE POLYMERS DOW CORNING EUROPE S.A. 2020-03-12 US disclosed
US-20190352466-A1 NOVEL MESOGEN-SILICON COMPOUND (CO)POLYMER AND THERMOPLASTIC ELASTOMER SHIN-ETSU CHEMICAL CO., LTD. (JP) 2019-11-21 US disclosed
US-20180163113-A1 HEAT DISSIPATION MATERIAL SHIN-ETSU CHEMICAL CO., LTD. (JP) 2018-06-14 US disclosed
EP-3153540-B1 PROCESS FOR PREPARING LINEAR CARBOSILOXANE POLYMERS DOW CORNING (US) 2018-06-06 EP disclosed
EP-3153540-A1 PROCESS FOR PREPARING LINEAR CARBOSILOXANE POLYMERS Dow Corning Corporation (US) 2017-04-12 EP disclosed