Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24915517 | 0.86 | KDM5A (0.34) | — | |
| SCHEMBL1829756 | 0.84 | ALOX15 (0.42) | HPGDTP53ALOX15MAPK1HSD17B10 | |
| SCHEMBL5444047 | 0.84 | STK25 (0.35) | HPGD | |
| SCHEMBL25746247 | 0.69 | ALDH1A1 (0.42) | HPGDTP53HSD17B10 | |
| SCHEMBL3465530 | 0.69 | — | — | |
| SCHEMBL28860793 | 0.68 | HCAR2 (0.53) | — | |
| SCHEMBL4264903 | 0.66 | — | — | |
| SCHEMBL25466531 | 0.66 | — | — | |
| SCHEMBL8348876 | 0.65 | — | — | |
| SCHEMBL12298687 | 0.65 | STK25 (0.35) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3617203-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2020-03-04 | — | — | EP | disclosed |
| US-10106530-B2 | Pyrazolyl substituted tetrahydropyranylsulfones | Grünenthal GmbH (DE) | 2018-10-23 | — | — | US | disclosed |
| US-20170101397-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170101397-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | TRPV1, CACNA1G, CACNA1B | HPGD 475/4885TP53 3998/4885ALOX15 1251/4885 |
| US-10106530-B2 | Pyrazolyl substituted tetrahydropyranylsulfones | TRPV1, CACNA1G, CACNA1B | HPGD 475/4885TP53 3998/4885ALOX15 1251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.