Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.70 |
| ▸ | RAB9A | P51151 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | NAMPT | P43490 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17998207 | 0.91 | HPGD (0.57) | HPGDRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL18532452 | 0.88 | ALDH1A1 (0.57) | HPGDRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL13499229 | 0.87 | ALDH1A1 (0.78) | HPGDRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL12301885 | 0.84 | NPC1 (0.76) | HPGDRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL3455416 | 0.84 | HPGD (0.76) | HPGDRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL387493 | 0.83 | L3MBTL1 (0.59) | RAB9ANPC1SMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL5183187 | 0.82 | HPGD (0.74) | HPGDRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL15985301 | 0.82 | L3MBTL1 (0.67) | RAB9ANPC1SMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL26646791 | 0.82 | HPGD (0.73) | HPGDRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL14296399 | 0.82 | SMN1; SMN2 (0.62) | HPGDRAB9ANPC1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190117773-A1 | Targeted Nanoparticles | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-04-25 | — | — | US | disclosed |
| US-10166291-B2 | Targeted nanoparticles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2019-01-01 | — | — | US | disclosed |
| US-20170296665-A1 | TARGETED NANOPARTICLES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2017-10-19 | — | — | US | disclosed |
| US-9610355-B2 | Carrier nanoparticles and related compositions, methods and systems | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10166291-B2 | Targeted nanoparticles | CLTB, NBAS, NAPA | HPGD 2282/4885RAB9A 664/4885NPC1 251/4885 |
| US-20190117773-A1 | Targeted Nanoparticles | CLTB, NBAS, NAPA | HPGD 2282/4885RAB9A 664/4885NPC1 251/4885 |
| US-20170296665-A1 | TARGETED NANOPARTICLES | CLTB, NBAS, NAPA | HPGD 2282/4885RAB9A 664/4885NPC1 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.