Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30570000 | 0.73 | — | — | |
| SCHEMBL526587 | 0.73 | — | — | |
| SCHEMBL327654 | 0.71 | CCNC (0.40) | CCNCCDK8CCNT1CDK9HASPIN | |
| SCHEMBL29952188 | 0.71 | CCNC (0.40) | CCNCCDK8CCNT1CDK9HASPIN | |
| SCHEMBL23748204 | 0.68 | CA12 (0.32) | CA12CA1CA2CA9CA14 | |
| SCHEMBL768221 | 0.68 | — | — | |
| SCHEMBL27773753 | 0.67 | CTRC (0.39) | CA12CA1CA2CA9CA14 | |
| SCHEMBL7957793 | 0.67 | CYP1A2 (0.40) | — | |
| SCHEMBL17573082 | 0.67 | CCNC (0.32) | CCNCCDK8 | |
| SCHEMBL36439 | 0.67 | CCNC (0.39) | CCNCCDK8CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2701512-B1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-04-05 | — | — | EP | disclosed |