Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | ERN1 | O75460 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29952188 | 1.00 | CCNC (0.40) | CCNCCDK8CYP2A6CYP2E1CYP2C8 | |
| SCHEMBL14872350 | 0.83 | CYP2A6 (0.42) | CCNCCDK8CYP2A6CYP2E1CYP2C8 | |
| SCHEMBL31068616 | 0.83 | CYP2A6 (0.42) | CCNCCDK8CYP2A6CYP2E1CYP2C8 | |
| SCHEMBL36439 | 0.82 | CCNC (0.39) | CCNCCDK8CYP2A6CYP2E1CYP2C8 | |
| SCHEMBL21505634 | 0.81 | CYP11B2 (0.39) | CCR1CCR5CCR8CCNT1CDK9 | |
| SCHEMBL9000433 | 0.77 | CCNC (0.36) | CCNCCDK8CYP2A6CYP2E1CYP2C8 | |
| SCHEMBL23748204 | 0.76 | CA12 (0.32) | CYP2A6CCR1CCR5CCR8CCNT1 | |
| SCHEMBL877689 | 0.75 | CYP2E1 (0.48) | CCNCCDK8CYP2A6CYP2E1CYP2C8 | |
| SCHEMBL2600757 | 0.75 | KMT2A (0.46) | CCNCCDK8CYP2A6CYP2E1CYP2D6 | |
| SCHEMBL29955436 | 0.75 | KMT2A (0.46) | CCNCCDK8CYP2A6CYP2E1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250129046-A1 | TETRAHYDROQUINOLINO DERIVATIVES FOR THE TREATMENT OF METASTATIC AND CHEMORESISTANT CANCERS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2025-04-24 | — | — | US | disclosed |
| US-12162855-B2 | Tetrahydroquinolino derivatives for the treatment of metastatic and chemoresistant cancers | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2024-12-10 | — | — | US | disclosed |
| EP-3830079-A1 | TETRAHYDROQUINOLINO DERIVATIVES FOR THE TREATMENT OF METASTATIC AND CHEMORESISTANT CANCERS | The Trustees of Princeton University (US) | 2021-06-09 | — | — | EP | disclosed |
| US-20210155602-A1 | TETRAHYDROQUINOLINO DERIVATIVES FOR THE TREATMENT OF METASTATIC AND CHEMORESISTANT CANCERS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2021-05-27 | — | — | US | disclosed |
| US-20210155602-A1 | TETRAHYDROQUINOLINO DERIVATIVES FOR THE TREATMENT OF METASTATIC AND CHEMORESISTANT CANCERS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2021-05-27 | — | — | US | disclosed |
| WO-2020028461-A1 | TETRAHYDROQUINOLINO DERIVATIVES FOR THE TREATMENT OF METASTATIC AND CHEMORESISTANT CANCERS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2020-02-06 | — | — | WO | disclosed |
| WO-2020028461-A1 | TETRAHYDROQUINOLINO DERIVATIVES FOR THE TREATMENT OF METASTATIC AND CHEMORESISTANT CANCERS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2020-02-06 | — | — | WO | disclosed |
| US-8134005-B2 | Preparation and use of magnesium amides | Ludwig-Maximilians-Universitat München (DE) | 2012-03-13 | — | — | US | disclosed |
| US-20090176988-A1 | Preparation and Use of Magnesium Amides | LUDWIG-MAXIMILIANS-UNIVERSITAT MUENCHEN (DE) | 2009-07-09 | — | — | US | disclosed |
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
| EP-0129791-A2 | Tetrahydropyridazinone derivatives, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1985-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210155602-A1 | TETRAHYDROQUINOLINO DERIVATIVES FOR THE TREATMENT OF METASTATIC AND CHEMORESISTANT CANCERS | ALDH3A1, ALDH1A3, ALDH2 | CCNC 2951/4885CDK8 2820/4885CYP2A6 1908/4885 |
| US-20250129046-A1 | TETRAHYDROQUINOLINO DERIVATIVES FOR THE TREATMENT OF METASTATIC AND CHEMORESISTANT CANCERS | ALDH3A1, ALDH1A1, ALDH2 | CCNC 2195/4885CDK8 1956/4885CYP2A6 768/4885 |
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRM1 | CCNC 2248/4885CDK8 1717/4885CYP2A6 1948/4885 |
| US-20090176988-A1 | Preparation and Use of Magnesium Amides | MLX, GLRX3, SFXN3 | CCNC 2706/4885CDK8 3548/4885CYP2A6 1456/4885 |
| US-12162855-B2 | Tetrahydroquinolino derivatives for the treatment of metastatic and chemoresistant cancers | ALDH3A1, ALDH2, ALDH1A1 | CCNC 2341/4885CDK8 2408/4885CYP2A6 1122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.