Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.57 |
| ▸ | SNCA | P37840 | 1/20 | 0.57 |
| ▸ | JUN | P05412 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003951 | 0.86 | NFE2L2 (0.71) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL3003953 | 0.86 | NFE2L2 (0.71) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL23023654 | 0.84 | KDM4E (0.67) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL8153885 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL8153880 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL30560923 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL9974139 | 0.82 | NFE2L2 (0.66) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL2743876 | 0.82 | NFKB1 (0.79) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL2743877 | 0.82 | NFKB1 (0.79) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL30493821 | 0.82 | NFKB1 (0.79) | KDM4EALDH1A1HPGDALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3549581-A2 | COMPOUNDS WITH (1E, 6E)-1,7-BIS-(3,4-DIMETHOXYPHENYL)-4,4-DISSTITUTED-HEPA-1,6-DIENE-3,5-DIONE STRUCTURAL SCAFFOLD, THEIR BIOLOGICAL ACTIVITY, AND USES THEREOF | Allianz Pharmascience Ltd (TW) | 2019-10-09 | — | — | EP | disclosed |
| EP-3150203-A1 | COMPOUNDS WITH (1E,6E)-1,7-BIS-(3,4- DIMETHOXYPHENYL)-4,4-DISSTITUTED-HEPA-1,6-DIENE-3,5-DI-ONE STRUCTURAL SCAFFOLD,THEIR BIOLOGICAL ACTIVITY, AND USES THEREOF | Allianz Pharmascience Ltd (TW) | 2017-04-05 | — | — | EP | disclosed |