Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18700220 | 0.86 | BTK (0.47) | BTKARALDH1A1KDM4EBRS3 | |
| SCHEMBL24518223 | 0.85 | PLA2G2A (0.47) | BTKALDH1A1MAPT | |
| SCHEMBL18700219 | 0.80 | BTK (0.48) | BTKBRS3MAOBPARP10MPO | |
| SCHEMBL25891692 | 0.77 | GAA (0.47) | ALDH1A1MAPTKDM4E | |
| SCHEMBL25891793 | 0.74 | GAA (0.43) | BTKALDH1A1PARP10 | |
| SCHEMBL8308326 | 0.72 | SIRT1 (0.45) | — | |
| SCHEMBL26859461 | 0.72 | MAPK1 (0.52) | BTKALDH1A1MAPTKDM4E | |
| SCHEMBL16197120 | 0.72 | SCN9A (0.50) | BTKPARP10 | |
| SCHEMBL25892423 | 0.68 | ALDH1A1 (0.44) | ALDH1A1MAPTKDM4E | |
| SCHEMBL19636003 | 0.68 | SCN4A (0.54) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2914586-B1 | BRUTON'S TYROSINE KINASE INHIBITORS | PFIZER (US) | 2017-04-05 | — | — | EP | disclosed |