Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | GALK1 | P51570 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9935648 | 0.82 | KDM4E (0.53) | KDM4EGPR3TDP1HTTHPGD | |
| SCHEMBL27279082 | 0.80 | KDM4E (0.52) | KDM4EGPR3HTTHPGDKMT2A | |
| SCHEMBL27588351 | 0.80 | KDM4E (0.52) | KDM4EGPR3HTTHPGDKMT2A | |
| SCHEMBL9935646 | 0.79 | KDM4E (0.53) | KDM4EGPR3TDP1HTTHPGD | |
| SCHEMBL28355479 | 0.77 | KDM4E (0.52) | KDM4EGPR3HTTHPGDKMT2A | |
| SCHEMBL5801178 | 0.77 | KDM4E (0.52) | KDM4EGPR3HTTKMT2ASMN1; SMN2 | |
| SCHEMBL1505063 | 0.77 | KDM4E (0.47) | KDM4EGPR3HTTKMT2ASMN1; SMN2 | |
| SCHEMBL28374660 | 0.77 | KDM4E (0.47) | KDM4EGPR3MTNR1AHTTHPGD | |
| SCHEMBL4033783 | 0.75 | KDM4E (0.49) | KDM4EGPR3KMT2AMEN1 | |
| SCHEMBL10976790 | 0.75 | KDM4E (0.49) | KDM4EGPR3HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947703-B2 | Phenanthridinium derivatives as DNA binding agents | UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 2011-05-24 | — | — | US | disclosed |
| US-20070249652-A1 | Phenanthridinium Derivatives as Dna Binding Agents | UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 2007-10-25 | — | — | US | disclosed |
| US-20070249652-A1 | Phenanthridinium Derivatives as Dna Binding Agents | UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 2007-10-25 | — | — | US | disclosed |
| EP-1692130-B1 | PHENANTHRIDINIUM DERIVATIVES AS DNA BINDING AGENTS | UNIV GLASGOW (GB) | 2007-08-08 | — | — | EP | disclosed |
| EP-1692130-B1 | PHENANTHRIDINIUM DERIVATIVES AS DNA BINDING AGENTS | UNIV GLASGOW (GB) | 2007-08-08 | — | — | EP | disclosed |
| EP-1692130-A2 | PHENANTHRIDINIUM DERIVATIVES AS DNA BINDING AGENTS | University Court of The University of Glasgow (GB) | 2006-08-23 | — | — | EP | disclosed |
| EP-1692130-A2 | PHENANTHRIDINIUM DERIVATIVES AS DNA BINDING AGENTS | University Court of The University of Glasgow (GB) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005054241-A3 | PHENANTHRIDINIUM DERIVATIVES AS DNA BINDING AGENTS | UNIV GLASGOW (GB) | 2005-07-28 | — | — | WO | disclosed |
| WO-2005054241-A2 | PHENANTHRIDINIUM DERIVATIVES AS DNA BINDING AGENTS | THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 2005-06-16 | — | — | WO | disclosed |
| WO-2005054241-A2 | PHENANTHRIDINIUM DERIVATIVES AS DNA BINDING AGENTS | THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249652-A1 | Phenanthridinium Derivatives as Dna Binding Agents | DNA2, DDB1, TOP2B | KDM4E 2276/4885GPR3 3483/4885PLAU 4853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.