Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.67 |
| ▸ | HTR1B | P28222 | 4/20 | 0.67 |
| ▸ | DRD3 | P35462 | 4/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.67 |
| ▸ | DRD2 | P14416 | 3/20 | 0.67 |
| ▸ | HTR1D | P28221 | 3/20 | 0.67 |
| ▸ | HTR6 | P50406 | 2/20 | 0.67 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.62 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.62 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.62 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.62 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.62 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.62 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.51 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | HTR5A | P47898 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13587273 | 0.82 | PSEN1 (0.59) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL264716 | 0.81 | PSEN1 (0.58) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL4298546 | 0.81 | HTR7 (1.00) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL4298542 | 0.81 | HTR7 (1.00) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL2563852 | 0.78 | HTR7 (0.53) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL3763606 | 0.75 | HTR7 (0.50) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL15276782 | 0.75 | SIRT2 (0.66) | SMN1; SMN2TP53HCRTR1HCRTR2 | |
| SCHEMBL15276784 | 0.74 | SIRT2 (0.64) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL5809151 | 0.74 | PSEN1 (0.57) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL5808164 | 0.73 | PSEN1 (0.56) | HTR7HTR1BDRD3HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10364256-B2 | Biaryl pyrazoles as NRF2 regulators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-30 | — | — | US | disclosed |
| US-10364256-B2 | Biaryl pyrazoles as NRF2 regulators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-30 | — | — | US | disclosed |
| US-20180282349-A1 | BIARYL PYRAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-10-04 | — | — | US | disclosed |
| WO-2017060854-A1 | BIARYL PYRAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-04-13 | — | — | WO | disclosed |
| WO-2017060854-A1 | BIARYL PYRAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10364256-B2 | Biaryl pyrazoles as NRF2 regulators | NFE2L2, KEAP1, NQO1 | HTR7 2905/4885HTR1B 2481/4885DRD3 3549/4885 |
| US-20180282349-A1 | BIARYL PYRAZOLES AS NRF2 REGULATORS | NFE2L2, KEAP1, NQO1 | HTR7 2905/4885HTR1B 2481/4885DRD3 3549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.