Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18686866 | 1.00 | HSD11B1 (0.39) | HSD11B1L3MBTL1ALDH1A1KMT2AKCNH2 | |
| SCHEMBL18716489 | 1.00 | HSD11B1 (0.39) | HSD11B1L3MBTL1ALDH1A1KMT2AKCNH2 | |
| SCHEMBL4182608 | 0.86 | HSD11B1 (0.39) | HSD11B1L3MBTL1ALDH1A1KMT2AKCNH2 | |
| SCHEMBL4170321 | 0.84 | MMP1 (0.39) | HSD11B1L3MBTL1ALDH1A1KMT2ALMNA | |
| SCHEMBL4181612 | 0.81 | HSD11B1 (0.36) | HSD11B1L3MBTL1ALDH1A1KCNH2LMNA | |
| SCHEMBL19433531 | 0.81 | SMN1; SMN2 (0.45) | HSD11B1L3MBTL1ALDH1A1KCNH2 | |
| SCHEMBL8620053 | 0.81 | HSD11B1 (0.40) | HSD11B1L3MBTL1ALDH1A1KCNH2TSHR | |
| SCHEMBL8870143 | 0.81 | HSD11B1 (0.40) | HSD11B1L3MBTL1ALDH1A1KCNH2TSHR | |
| SCHEMBL8620049 | 0.81 | HSD11B1 (0.40) | HSD11B1L3MBTL1ALDH1A1KCNH2TSHR | |
| SCHEMBL9368035 | 0.80 | L3MBTL1 (0.40) | HSD11B1L3MBTL1ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3269721-B1 | BICYCLIC PYRIDINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2021-04-07 | — | — | EP | disclosed |
| EP-3150581-A1 | PYRIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2017-04-05 | — | — | EP | disclosed |