Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | HTR3A | P46098 | 4/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18674333 | 0.75 | LMNA (0.49) | LMNAHTR1AHTR3ASLC6A2SLC6A4 | |
| SCHEMBL7537968 | 0.71 | ADK (0.38) | LMNAHTR1AGSK3BALDH1A1HTT | |
| SCHEMBL11886348 | 0.67 | KDM4E (0.46) | GSK3BNPSR1TSHRALDH1A1 | |
| SCHEMBL21972241 | 0.67 | LMNA (0.41) | LMNAHTR3ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11689786 | 0.66 | ACHE (0.43) | LMNAPBRM1ALDH1A1 | |
| SCHEMBL30701084 | 0.65 | CYP1A2 (0.39) | LMNAGSK3BTSHRALDH1A1 | |
| SCHEMBL20027221 | 0.64 | GPR3 (0.39) | TSHRALDH1A1P2RX4HTT | |
| SCHEMBL16728888 | 0.64 | GPR3 (0.39) | TSHRALDH1A1P2RX4HTT | |
| SCHEMBL11044842 | 0.64 | MAOB (0.40) | HTR1A | |
| SCHEMBL13023294 | 0.64 | P2RX4 (0.45) | NPSR1ALDH1A1P2RX4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3153501-A1 | GLUCAGON ANTAGONISTS | Metabasis Therapeutics, Inc. (US) | 2017-04-12 | — | — | EP | disclosed |