Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12109509 | 0.75 | ALDH1A1 (0.58) | ALDH1A1MAPTKDM4EPKMHPGD | |
| SCHEMBL6625448 | 0.73 | ALDH1A1 (0.56) | ALDH1A1MAPTKDM4EPKMHPGD | |
| SCHEMBL16307579 | 0.71 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EPKMHPGD | |
| SCHEMBL2457137 | 0.70 | RAB9A (0.67) | ALDH1A1MAPTKDM4EPKMHPGD | |
| SCHEMBL29438978 | 0.68 | ALDH1A1 (0.61) | ALDH1A1MAPTKDM4EPKMHPGD | |
| SCHEMBL7590755 | 0.68 | ALDH1A1 (0.61) | ALDH1A1MAPTKDM4EPKMHPGD | |
| SCHEMBL19889060 | 0.68 | RAB9A (0.56) | ALDH1A1MAPTKDM4EHPGDRAB9A | |
| SCHEMBL266609 | 0.67 | ALDH1A1 (0.66) | ALDH1A1MAPTKDM4EPKMHPGD | |
| SCHEMBL29727934 | 0.67 | ALDH1A1 (0.66) | ALDH1A1MAPTKDM4EPKMHPGD | |
| SCHEMBL7846427 | 0.67 | MAPT (0.56) | ALDH1A1MAPTKDM4EPKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2809668-B1 | 4-(BENZOIMIDAZOL-2-YL)-THIAZOLE COMPOUNDS AND RELATED AZA DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2017-04-12 | — | — | EP | disclosed |