Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935854 | 0.92 | SMN1; SMN2 (0.46) | ADORA2AADORA1ADORA3ADORA2BCYP1A2 | |
| SCHEMBL1881207 | 0.86 | SMN1; SMN2 (0.56) | CYP1A2SMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL1879617 | 0.81 | ADORA3 (0.47) | ADORA2AADORA1ADORA3ADORA2BSMN1; SMN2 | |
| SCHEMBL21236762 | 0.80 | ADORA3 (0.43) | ADORA2AADORA1ADORA3ADORA2BCYP1A2 | |
| SCHEMBL3466836 | 0.80 | GAA (0.47) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL1878308 | 0.79 | KDM4E (0.57) | ADORA2AADORA1ADORA3SMN1; SMN2KDM4E | |
| SCHEMBL1875365 | 0.79 | LMNA (0.52) | ADORA2AADORA1ADORA3ADORA2BCYP1A2 | |
| SCHEMBL1878740 | 0.78 | ADORA3 (0.45) | ADORA2AADORA1ADORA3ADORA2BSMN1; SMN2 | |
| SCHEMBL17267082 | 0.78 | ADORA3 (0.43) | ADORA2AADORA1ADORA3ADORA2BCYP1A2 | |
| SCHEMBL1872946 | 0.77 | ADORA3 (0.42) | ADORA2AADORA1ADORA3ADORA2BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059503-B1 | AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME | KOREA RES INST CHEM TECH (KR) | 2015-08-26 | — | — | EP | disclosed |
| US-7939550-B2 | Aminopyrazole derivatives, process for the preparation thereof, and composition for preventing or treating ischemic diseases containing the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-05-10 | — | — | US | disclosed |
| US-20100063106-A1 | AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-03-11 | — | — | US | disclosed |
| EP-2059503-A1 | AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME | Korea Research Institute Of Chemical Technology (KR) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008051047-A1 | AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063106-A1 | AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME | CASP3, ABAT, AIFM1 | ADORA2A 405/4885ADORA1 252/4885ADORA3 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.