Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.45 |
| ▸ | MTOR | P42345 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18739484 | 0.89 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL18739097 | 0.87 | PIK3CA (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL18739092 | 0.87 | PIK3CA (0.46) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL18739184 | 0.87 | ALDH1A1 (0.52) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL18739117 | 0.85 | ALDH1A1 (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL18739629 | 0.81 | MET (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL30808177 | 0.81 | MET (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL18739603 | 0.81 | PIK3CD (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL18739760 | 0.81 | KMT2A (0.46) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL18739162 | 0.81 | PIK3CB (0.67) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3359533-B1 | QUINOXALINE AND PYRIDOPYRAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-11-17 | — | — | EP | disclosed |
| WO-2017060406-A1 | QUINOXALINE AND PYRIDOPYRAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-04-13 | — | — | WO | disclosed |