Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18739759 | 0.89 | KDM4E (0.46) | KMT2AMAPTSMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL18739629 | 0.86 | MET (0.47) | KMT2AMAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL30808177 | 0.86 | MET (0.47) | KMT2AMAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL30808213 | 0.86 | MET (0.46) | KMT2AMAPTSMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL30808159 | 0.83 | MET (0.49) | — | |
| SCHEMBL18739484 | 0.82 | PIK3CA (0.49) | KDM4EALDH1A1HTTHSD17B10HPGD | |
| SCHEMBL18739734 | 0.81 | ALDH1A1 (0.40) | KMT2AMAPTSMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL18739730 | 0.81 | PIK3CB (0.41) | SMN1; SMN2PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL18739601 | 0.81 | PIK3CA (0.45) | SMN1; SMN2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL18739603 | 0.81 | PIK3CD (0.41) | SMN1; SMN2KDM4EALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3359533-B1 | QUINOXALINE AND PYRIDOPYRAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-11-17 | — | — | EP | disclosed |
| WO-2017060406-A1 | QUINOXALINE AND PYRIDOPYRAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-04-13 | — | — | WO | disclosed |