Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR1D | P28221 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 8/20 | 0.47 |
| ▸ | MAOB | P27338 | 8/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768023 | 1.00 | HTR1A (0.51) | HTR1AHTR1DHTR2CDYRK1AMAOA | |
| SCHEMBL926708 | 0.85 | DYRK1A (0.48) | DYRK1AMAOAMAOBFTOACHE | |
| SCHEMBL30768028 | 0.84 | TTR (0.51) | DYRK1AMAOAMAOBFTOACHE | |
| SCHEMBL6620745 | 0.84 | TTR (0.51) | DYRK1AMAOAMAOBFTOACHE | |
| SCHEMBL3662195 | 0.84 | DYRK1A (0.55) | DYRK1AMAOAMAOBFTOACHE | |
| SCHEMBL32670130 | 0.83 | NPC1 (0.50) | DYRK1AMAOAMAOBFTOACHE | |
| SCHEMBL30768058 | 0.79 | NQO2 (0.50) | DYRK1AMAOAMAOBFTOACHE | |
| SCHEMBL30768019 | 0.79 | MAOA (0.43) | HTR1AHTR1DHTR2CDYRK1AMAOA | |
| SCHEMBL29160425 | 0.79 | MAOA (0.43) | HTR1AHTR1DHTR2CDYRK1AMAOA | |
| SCHEMBL30768009 | 0.79 | NQO2 (0.50) | DYRK1AMAOAMAOBFTOACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117615763-A | Phosphoinositide 3 kinase beta inhibitor, composition and preparation method thereof | 健道生物医药有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-104447657-B | There is the chromene ketone derivatives of anti-tumor activity | 阿斯利康(瑞典)有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-102712615-A | Chromenone Derivatives with Antitumor Activity | ASTRAZENECA AB | 2012-10-03 | — | — | CN | disclosed |
| EP-2493870-A1 | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | AstraZeneca AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051704-A1 | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2011-05-05 | — | — | WO | disclosed |