Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 7/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 7/20 | 0.48 |
| ▸ | MAOB | P27338 | 7/20 | 0.48 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.48 |
| ▸ | STS | P08842 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768028 | 1.00 | TTR (0.51) | TTRACHEMAOAMAOBFTO | |
| SCHEMBL2387259 | 0.87 | DYRK1A (0.56) | TTRACHEMAOAMAOBFTO | |
| SCHEMBL30768023 | 0.84 | HTR1A (0.51) | ACHEMAOAMAOBFTODYRK1A | |
| SCHEMBL1874005 | 0.84 | HTR1A (0.51) | ACHEMAOAMAOBFTODYRK1A | |
| SCHEMBL32670130 | 0.84 | NPC1 (0.50) | ACHEMAOAMAOBFTODYRK1A | |
| SCHEMBL30768019 | 0.80 | MAOA (0.43) | ACHEMAOAMAOBFTODYRK1A | |
| SCHEMBL29160425 | 0.80 | MAOA (0.43) | ACHEMAOAMAOBFTODYRK1A | |
| SCHEMBL30768009 | 0.80 | NQO2 (0.50) | ACHEMAOAMAOBFTODYRK1A | |
| SCHEMBL30768058 | 0.80 | NQO2 (0.50) | ACHEMAOAMAOBFTODYRK1A | |
| SCHEMBL926708 | 0.79 | DYRK1A (0.48) | ACHEMAOAMAOBFTODYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117615763-A | Phosphoinositide 3 kinase beta inhibitor, composition and preparation method thereof | 健道生物医药有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-104447657-B | There is the chromene ketone derivatives of anti-tumor activity | 阿斯利康(瑞典)有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-103596948-B | Benzopyranone compounds as PI 3-kinase inhibitors for the treatment of cancer | ASTRAZENECA AB (SE) | 2016-04-27 | — | — | CN | disclosed |
| CN-104447657-A | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB | 2015-03-25 | — | — | CN | disclosed |
| CN-102712615-B | Chromenone Derivatives with Antitumor Activity | ASTRAZENECA AB | 2014-12-17 | — | — | CN | disclosed |
| US-20040116497-A1 | Chromane derivatives, process for their preparation and their use as antitumor agents | PHARMACIA ITALIA SPA (IT) | 2004-06-17 | — | — | US | disclosed |
| EP-1379524-A2 | CHROMANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002070515-A2 | CHROMANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2002-09-12 | — | — | WO | disclosed |