⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541845 | 0.76 | AKR1B1 (0.30) | — | |
| SCHEMBL3441481 | 0.72 | AKR1B1 (0.34) | — | |
| SCHEMBL9300148 | 0.69 | LMNA (0.38) | — | |
| SCHEMBL8025665 | 0.69 | LMNA (0.38) | — | |
| SCHEMBL8332379 | 0.69 | LMNA (0.39) | — | |
| SCHEMBL15966786 | 0.69 | LMNA (0.39) | — | |
| SCHEMBL10335813 | 0.67 | LMNA (0.42) | — | |
| SCHEMBL343765 | 0.67 | LMNA (0.42) | — | |
| SCHEMBL15152173 | 0.67 | LMNA (0.42) | — | |
| SCHEMBL20296909 | 0.66 | LMNA (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3362564-B1 | NUCLEIC ACID BASED TIA-1 INHIBITORS | AQUINNAH PHARMACEUTICALS INC (US) | 2020-07-01 | — | — | EP | disclosed |
| US-20190142860-A1 | NUCLEIC ACID BASED TIA-1 INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-05-16 | — | — | US | disclosed |
| EP-3362564-A1 | NUCLEIC ACID BASED TIA-1 INHIBITORS | Aquinnah Pharmaceuticals Inc. (US) | 2018-08-22 | — | — | EP | disclosed |
| WO-2017066657-A1 | NUCLEIC ACID BASED TIA-1 INHIBITORS | AQUINNAH PHARMACEUTICALS, INC. (US) | 2017-04-20 | — | — | WO | disclosed |