SCHEMBL18740641

SCHEMBL18740641

Cc1ccc2c(Cl)nsc2c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.45
MCL1 Q07820 1/20 0.45
RAB9A P51151 8/20 0.39
MAPT P10636 5/20 0.39
NPC1 O15118 7/20 0.39
LMNA P02545 3/20 0.39
GAA P10253 2/20 0.39
SMN1; SMN2 Q16637 4/20 0.37
PPARG P37231 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
NR2E3 Q9Y5X4 1/20 0.37
NCOR2 Q9Y618 1/20 0.37
KDM4E B2RXH2 3/20 0.36
PKM P14618 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
PARP15 Q460N3 2/20 0.34
PARP14 Q460N5 2/20 0.34
PARP10 Q53GL7 2/20 0.34
TNKS2 Q9H2K2 2/20 0.34
PARP2 Q9UGN5 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8391143 0.84 LMNA (0.39) BCL2L1MCL1MAPTLMNANPSR1
SCHEMBL23479167 0.79 RAB9A (0.44) RAB9AMAPTNPC1LMNASMN1; SMN2
SCHEMBL8388159 0.79 KDM4E (0.42) MCL1RAB9AMAPTNPC1LMNA
SCHEMBL5985788 0.79 MAPT (0.37) BCL2L1MCL1RAB9AMAPTNPC1
SCHEMBL14861787 0.76 MIF (0.38) RAB9AMAPTNPC1GAAKDM4E
SCHEMBL8124099 0.76 BCKDK (0.45) RAB9AMAPTNPC1LMNASMN1; SMN2
SCHEMBL8269239 0.76 MAPT (0.53) BCL2L1MCL1RAB9AMAPTNPC1
SCHEMBL2430946 0.76 PARP10 (0.38) BCL2L1MCL1RAB9AMAPTNPC1
SCHEMBL20049315 0.76 ITK (0.36) BCL2L1MCL1RAB9AMAPTLMNA
SCHEMBL23478523 0.76 KIF11 (0.39) RAB9AMAPTNPC1LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3860990-A1 INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF CANCER Inventiva (FR) 2021-08-11 EP disclosed
WO-2021113698-A1 MASP-2 INHIBITORS AND METHODS OF USE OMEROS CORPORATION (US) 2021-06-10 WO disclosed
WO-2020070181-A1 INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF CANCER INVENTIVA (FR) 2020-04-09 WO disclosed
EP-3362448-A1 NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA Inventiva (FR) 2018-08-22 EP disclosed
WO-2017064277-A1 NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA INVENTIVA (FR) 2017-04-20 WO disclosed