Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | G6PD | P11413 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | CASP6 | P55212 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4363322 | 0.82 | G6PD (0.57) | G6PDCASP7CASP6MMP2ALDH1A1 | |
| SCHEMBL7757318 | 0.79 | ALDH1A1 (0.56) | MMP2ALDH1A1ALOX15HSD17B10NAPRT | |
| SCHEMBL526919 | 0.79 | G6PD (0.74) | G6PDCASP7CASP6MMP2ALDH1A1 | |
| SCHEMBL11147524 | 0.78 | ALDH1A1 (0.52) | G6PDCASP7CASP6MMP2ALDH1A1 | |
| SCHEMBL28281319 | 0.77 | G6PD (0.71) | G6PDCASP7CASP6MMP2ALDH1A1 | |
| SCHEMBL30806223 | 0.77 | G6PD (0.71) | G6PDCASP7CASP6MMP2ALDH1A1 | |
| SCHEMBL28500431 | 0.77 | G6PD (0.50) | G6PDCASP7CASP6MMP2ALDH1A1 | |
| SCHEMBL18740672 | 0.73 | MMP2 (0.55) | G6PDCASP7CASP6MMP2ALDH1A1 | |
| SCHEMBL30797265 | 0.73 | G6PD (0.65) | G6PDCASP7CASP6MMP2ALDH1A1 | |
| SCHEMBL9851131 | 0.73 | G6PD (0.65) | G6PDCASP7CASP6MMP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3362448-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | Inventiva (FR) | 2018-08-22 | — | — | EP | claimed |
| WO-2017064277-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | INVENTIVA (FR) | 2017-04-20 | — | — | WO | claimed |
| EP-3362448-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | Inventiva (FR) | 2018-08-22 | — | — | EP | disclosed |
| WO-2017064277-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | INVENTIVA (FR) | 2017-04-20 | — | — | WO | disclosed |