Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 6/20 | 0.49 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | PNP | P00491 | 2/20 | 0.47 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.47 |
| ▸ | HINT1 | P49773 | 1/20 | 0.45 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.45 |
| ▸ | KRAS | P01116 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19774687 | 0.86 | NT5E (0.49) | NT5EPOLBTAS1R3TAS1R1IMPDH2 | |
| SCHEMBL15468735 | 0.84 | NT5E (0.57) | NT5EPOLBTAS1R3TAS1R1IMPDH2 | |
| SCHEMBL12194800 | 0.84 | NT5E (0.57) | NT5EPOLBTAS1R3TAS1R1IMPDH2 | |
| SCHEMBL12939473 | 0.84 | NT5E (0.57) | NT5EPOLBTAS1R3TAS1R1IMPDH2 | |
| SCHEMBL10819909 | 0.84 | NT5E (0.57) | NT5EPOLBTAS1R3TAS1R1IMPDH2 | |
| SCHEMBL1577230 | 0.84 | NT5E (0.57) | NT5EPOLBTAS1R3TAS1R1IMPDH2 | |
| SCHEMBL15831212 | 0.83 | NT5E (0.53) | NT5EPOLBTAS1R3TAS1R1IMPDH2 | |
| SCHEMBL18271830 | 0.83 | P2RX3 (0.45) | POLBTGM2PNPFUT5KRAS | |
| SCHEMBL18290456 | 0.83 | P2RX3 (0.45) | POLBTGM2PNPFUT5KRAS | |
| SCHEMBL31552867 | 0.82 | TAS1R3 (0.49) | NT5EPOLBTAS1R3TAS1R1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624249-B2 | Nucleoside kinase bypass compositions and methods | MERCK SHARP & DOHME CORP. (US) | 2017-04-18 | — | — | US | disclosed |