Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 12/20 | 0.58 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.58 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.58 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.58 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.58 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.58 |
| ▸ | LPAR6 | P43657 | 2/20 | 0.58 |
| ▸ | CES2 | O00748 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.58 |
| ▸ | P2RY10 | O00398 | 3/20 | 0.41 |
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.41 |
| ▸ | GPR34 | Q9UPC5 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14407661 | 0.87 | DGKA (0.41) | LPAR1ENPP2LPAR5LPAR4LPAR2 | |
| SCHEMBL6348381 | 0.82 | LPAR1 (0.53) | LPAR1ENPP2LPAR5LPAR4LPAR2 | |
| SCHEMBL20078088 | 0.79 | LPAR1 (0.81) | LPAR1ENPP2LPAR5LPAR4LPAR2 | |
| SCHEMBL2932890 | 0.79 | LPAR1 (0.77) | LPAR1ENPP2LPAR5LPAR4LPAR2 | |
| SCHEMBL13176692 | 0.79 | LPAR1 (0.77) | LPAR1ENPP2LPAR5LPAR4LPAR2 | |
| SCHEMBL19960604 | 0.78 | LPAR1 (0.67) | LPAR1ENPP2LPAR5LPAR4LPAR2 | |
| SCHEMBL2867416 | 0.78 | LPAR1 (0.50) | LPAR1ENPP2LPAR5LPAR4LPAR2 | |
| SCHEMBL14058714 | 0.76 | LPAR1 (0.63) | LPAR1ENPP2LPAR5LPAR4LPAR2 | |
| SCHEMBL27784094 | 0.75 | LPAR1 (0.97) | LPAR1ENPP2LPAR5LPAR4LPAR2 | |
| SCHEMBL2932933 | 0.75 | LPAR1 (0.97) | LPAR1ENPP2LPAR5LPAR4LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9622993-B2 | Thiosemicarbazones inhibitors of lysophosphatidic acid acyltransferase and uses thereof | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-04-18 | — | — | US | disclosed |