Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM6B | O15054 | 1/20 | 0.30 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127066 | 0.78 | KDM4E (0.30) | — | |
| SCHEMBL1127309 | 0.68 | — | — | |
| SCHEMBL1127174 | 0.67 | — | — | |
| SCHEMBL9329272 | 0.66 | TSHR (0.44) | ALDH1A1SMN1; SMN2CYP19A1GAAMAPT | |
| SCHEMBL1127127 | 0.66 | NPC1 (0.32) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7162154 | 0.65 | TSHR (0.41) | ALDH1A1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL11663103 | 0.65 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL11498178 | 0.64 | TRPM8 (0.53) | ALDH1A1SMN1; SMN2GAALMNAMEN1 | |
| SCHEMBL16233058 | 0.64 | AKR1B1 (0.47) | ALDH1A1SMN1; SMN2GAAMAPTLMNA | |
| SCHEMBL1554489 | 0.63 | JAK2 (0.51) | ALDH1A1SMN1; SMN2CYP19A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |